View source for 2rqf


==Solution structure of juvenile hormone binding protein from silkworm in complex with JH III==
<StructureSection load='2rqf' size='340' side='right'caption='[[2rqf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JH3:METHYL+(2E,6E)-9-[(2R)-3,3-DIMETHYLOXIRAN-2-YL]-3,7-DIMETHYLNONA-2,6-DIENOATE'>JH3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqf OCA], [https://pdbe.org/2rqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqf RCSB], [https://www.ebi.ac.uk/pdbsum/2rqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9U556_BOMMO Q9U556_BOMMO] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqf ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Juvenile hormone (JH) plays crucial roles in many aspects of the insect life. All the JH actions are initiated by transport of JH in the hemolymph as a complex with JH-binding protein (JHBP) to target tissues. Here, we report structural mechanism of JH delivery by JHBP based upon the crystal and solution structures of apo and JH-bound JHBP. In solution, apo-JHBP exists in equilibrium of multiple conformations with different orientations of the gate helix for the hormone-binding pocket ranging from closed to open forms. JH-binding to the gate-open form results in the fully closed JHBP-JH complex structure where the bound JH is completely buried inside the protein. JH-bound JHBP opens the gate helix to release the bound hormone likely by sensing the less polar environment at the membrane surface of target cells. This is the first report that provides structural insight into JH signaling.

Structural mechanism of JH delivery in hemolymph by JHBP of silkworm, Bombyx mori.,Suzuki R, Fujimoto Z, Shiotsuki T, Tsuchiya W, Momma M, Tase A, Miyazawa M, Yamazaki T Sci Rep. 2011;1:133. doi: 10.1038/srep00133. Epub 2011 Oct 28. PMID:22355650<ref>PMID:22355650</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2rqf" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bombyx mori]]
[[Category: Large Structures]]
[[Category: Fujimoto Z]]
[[Category: Momma M]]
[[Category: Shiotsuki T]]
[[Category: Suzuki R]]
[[Category: Tase A]]
[[Category: Yamazaki T]]