View source for 2rqh


==Structure of GSPT1/ERF3A-PABC==
<StructureSection load='2rqh' size='340' side='right'caption='[[2rqh]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqh OCA], [https://pdbe.org/2rqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqh RCSB], [https://www.ebi.ac.uk/pdbsum/2rqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ERF3A_MOUSE ERF3A_MOUSE] Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqh ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Hoshino T]]
[[Category: Hosoda N]]
[[Category: Katada I]]
[[Category: Nakanishi T]]
[[Category: Osawa M]]
[[Category: Shimada I]]
[[Category: Uchida S]]