View source for 2rrq


==DNA oligomer containing propylene cross-linked cyclic 2'-deoxyuridylate dimer==
<StructureSection load='2rrq' size='340' side='right'caption='[[2rrq]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rrq]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JDT:2-DEOXY-5-ETHYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>JDT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrq OCA], [https://pdbe.org/2rrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrq RCSB], [https://www.ebi.ac.uk/pdbsum/2rrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrq ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
High Mobility Group Box 1 (HMGB1) protein, a potential therapeutic target, binds bent DNAs structure-specifically. Here we report on a crucial structural feature of the bent DNA required for strong binding to HMGB1. NMR structures of two bent DNA oligomers, only one of which binds strongly to HMGB1, revealed that the presence of a pocket structure on the minor groove is crucial for strong binding through penetration of a phenylalanine residue.

Structural feature of bent DNA recognized by HMGB1.,Furuita K, Murata S, Jee JG, Ichikawa S, Matsuda A, Kojima C J Am Chem Soc. 2011 Apr 20;133(15):5788-90. Epub 2011 Mar 28. PMID:21443191<ref>PMID:21443191</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2rrq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Furuita K]]
[[Category: Ichikawa S]]
[[Category: Jee JG]]
[[Category: Kojima C]]
[[Category: Matsuda A]]
[[Category: Murata S]]