View source for 2rru


==Solution structure of the UBA omain of p62 and its interaction with ubiquitin==
<StructureSection load='2rru' size='340' side='right'caption='[[2rru]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRU FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rru OCA], [https://pdbe.org/2rru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rru RCSB], [https://www.ebi.ac.uk/pdbsum/2rru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rru ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref> 

==See Also==
*[[Sequestosome|Sequestosome]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Arita K]]
[[Category: Hasegawa J]]
[[Category: Isogai S]]
[[Category: Komatsu M]]
[[Category: Morimoto D]]
[[Category: Shirakawa M]]
[[Category: Sou Y]]
[[Category: Tanaka K]]
[[Category: Tenno T]]
[[Category: Tochio H]]
[[Category: Unzai S]]