View source for 2rue


==Solution structure of the a' domain of thermophilic fungal protein disulfide (oxidized form, 303K)==
<StructureSection load='2rue' size='340' side='right'caption='[[2rue]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rue]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RUE FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rue OCA], [https://pdbe.org/2rue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rue RCSB], [https://www.ebi.ac.uk/pdbsum/2rue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rue ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDI_HUMIN PDI_HUMIN] Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer (By similarity).
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== Publication Abstract from PubMed ==
Protein disulfide isomerase functions as a folding catalyst in the endoplasmic reticulum. Its b' and a' domains provide substrate-binding sites and undergo a redox-dependent domain rearrangement coupled to an open-closed structural change. Here we determined the first solution structure of the a' domain in its oxidized form and thereby demonstrate that oxidation of the a' domain induces significant conformational changes not only in the vicinity of the active site but also in the distal b'-interfacial segment. Based on these findings, we propose that this conformational transition triggers the domain segregation coupled with the exposure of the hydrophobic surface.

Redox-coupled structural changes of the catalytic a' domain of protein disulfide isomerase.,Inagaki K, Satoh T, Yagi-Utsumi M, Le Gulluche AC, Anzai T, Uekusa Y, Kamiya Y, Kato K FEBS Lett. 2015 Aug 10. pii: S0014-5793(15)00689-4. doi:, 10.1016/j.febslet.2015.07.041. PMID:26272828<ref>PMID:26272828</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2rue" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Humicola insolens]]
[[Category: Large Structures]]
[[Category: Inagaki K]]
[[Category: Kato K]]
[[Category: Satoh T]]