View source for 2vtw


==Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre==
<StructureSection load='2vtw' size='340' side='right'caption='[[2vtw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2vtw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Fowl_aviadenovirus_1 Fowl aviadenovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VTW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vtw OCA], [https://pdbe.org/2vtw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vtw RCSB], [https://www.ebi.ac.uk/pdbsum/2vtw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vtw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPIK2_ADEG1 SPIK2_ADEG1] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
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== Publication Abstract from PubMed ==
There are more than 100 known adenovirus serotypes, including 50 human serotypes. They can infect all 5 major vertebrate classes but only Aviadenovirus infecting birds and Mastadenovirus infecting mammals have been well studied. CELO (chicken embryo lethal orphan) adenovirus is responsible for mild respiratory pathologies in birds. Most studies on CELO virus have focussed on its genome sequence and organisation whereas the structural work on CELO proteins has only recently started. Contrary to most adenoviruses, the vertices of CELO virus reveal pentons with two fibres of different lengths. The distal parts (or head) of those fibres are involved in cellular receptor binding. Here we have determined the atomic structure of the short-fibre head of CELO (amino acids 201-410) at 2.0 A resolution. Despite low sequence identity, this structure is conserved compared to the other adenovirus fibre heads. We have used the existing CELO long-fibre head structure and the one we show here for a structure-based alignment of 11 known adenovirus fibre heads which was subsequently used for the construction of an evolutionary tree. Both the fibre head sequence and structural alignments suggest that enteric human group F adenovirus 41 (short fibre) is closer to the CELO fibre heads than the canine CAdV-2 fibre head, that lies closer to the human virus fibre heads.

Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre.,El Bakkouri M, Seiradake E, Cusack S, Ruigrok RW, Schoehn G Virology. 2008 Aug 15;378(1):169-76. Epub 2008 Jun 17. PMID:18561970<ref>PMID:18561970</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fowl aviadenovirus 1]]
[[Category: Large Structures]]
[[Category: Cusack S]]
[[Category: ElBakkouri M]]
[[Category: Ruigrok RWH]]
[[Category: Schoehn G]]
[[Category: Seiradake E]]