View source for 2w8m


==Structure of D212, a nuclease from a fusselovirus.==
<StructureSection load='2w8m' size='340' side='right'caption='[[2w8m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2w8m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_virus_Ragged_Hills Sulfolobus virus Ragged Hills]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W8M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8m OCA], [https://pdbe.org/2w8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w8m RCSB], [https://www.ebi.ac.uk/pdbsum/2w8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w8m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6TRV5_9VIRU Q6TRV5_9VIRU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structural studies have made significant contributions to our understanding of Sulfolobus spindle-shaped viruses (Fuselloviridae), an important model system for archaeal viruses. Continuing these efforts, we report the structure of D212 from Sulfolobus spindle-shaped virus Ragged Hills. The overall fold and conservation of active site residues place D212 in the PD-(D/E)XK nuclease superfamily. The greatest structural similarity is found to the archaeal Holliday junction cleavage enzymes, strongly suggesting a role in DNA replication, repair, or recombination. Other roles associated with nuclease activity are also considered.

The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily.,Menon SK, Eilers BJ, Young MJ, Lawrence CM J Virol. 2010 Jun;84(12):5890-7. Epub 2010 Apr 7. PMID:20375162<ref>PMID:20375162</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2w8m" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Sulfolobus virus Ragged Hills]]
[[Category: Lawrence CM]]
[[Category: Menon SK]]
[[Category: Young MJ]]