View source for 2wle


==Crystallographic analysis of the polysialic acid O-acetyltransferase OatWY==
<StructureSection load='2wle' size='340' side='right'caption='[[2wle]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2wle]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_Y Neisseria meningitidis serogroup Y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wle OCA], [https://pdbe.org/2wle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wle RCSB], [https://www.ebi.ac.uk/pdbsum/2wle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wle ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OATWY_NEIME OATWY_NEIME] Catalyzes the O-acetylation of capsular polymeric sialic acid consisting of polymers of (2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl residues. Shows high substrate specificity toward polymers of sialic acid that contains a large number of residues.<ref>PMID:19525232</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wle_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wle ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Neisseria meningitidis serogroup Y]]
[[Category: Gilbert M]]
[[Category: Lee HJ]]
[[Category: Rakic B]]
[[Category: Strynadka NCJ]]
[[Category: Wakarchuk WW]]
[[Category: Withers SG]]