View source for 2wns

==HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRTASE) DOMAIN OF URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMPS) IN COMPLEX WITH ITS SUBSTRATE OROTIDINE 5'-MONOPHOSPHATE (OMP)==
<StructureSection load='2wns' size='340' side='right' caption='[[2wns]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2wns]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OMP:OROTIDINE-5-MONOPHOSPHATE'>OMP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jgy|2jgy]], [[2v30|2v30]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wns OCA], [http://pdbe.org/2wns PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wns RCSB], [http://www.ebi.ac.uk/pdbsum/2wns PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wns_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wns ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Orotate phosphoribosyltransferase]]
[[Category: Arrowsmith, C H]]
[[Category: Berglund, H]]
[[Category: Bountra, C]]
[[Category: Collins, R]]
[[Category: Edwards, A M]]
[[Category: Flodin, S]]
[[Category: Flores, A]]
[[Category: Graslund, S]]
[[Category: Hammarstrom, M]]
[[Category: Johansson, A]]
[[Category: Johansson, I]]
[[Category: Karlberg, T]]
[[Category: Kotyenova, T]]
[[Category: Kotzch, A]]
[[Category: Moche, M]]
[[Category: Nielsen, T K]]
[[Category: Nordlund, P]]
[[Category: Nyman, T]]
[[Category: Persson, C]]
[[Category: Roos, A]]
[[Category: Sagemark, J]]
[[Category: Schueler, H]]
[[Category: Schutz, P]]
[[Category: Siponen, M I]]
[[Category: Svensson, L]]
[[Category: Thorsell, A G]]
[[Category: Tresaugues, L]]
[[Category: Vandenberg, S]]
[[Category: Weigelt, J]]
[[Category: Welin, M]]
[[Category: Wisniewska, M]]
[[Category: Decarboxylase]]
[[Category: Disease mutation]]
[[Category: Glycosyltransferase]]
[[Category: Lyase]]
[[Category: Multifunctional enzyme]]
[[Category: Phosphoprotein]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Transferase]]