View source for 2xpz


==Structure of native yeast LTA4 hydrolase==
<StructureSection load='2xpz' size='340' side='right'caption='[[2xpz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XPZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpz OCA], [https://pdbe.org/2xpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xpz RCSB], [https://www.ebi.ac.uk/pdbsum/2xpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xpz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LKHA4_YEAST LKHA4_YEAST] Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA(4) to form LTB(4) (in vitro).<ref>PMID:10574934</ref> <ref>PMID:11601994</ref> <ref>PMID:16024909</ref> <ref>PMID:16597475</ref> <ref>PMID:21146536</ref> 

==See Also==
*[[Leukotriene A4 Hydrolase|Leukotriene A4 Hydrolase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Haeggstrom JZ]]
[[Category: Hasan M]]
[[Category: Helgstrand C]]
[[Category: Thunnissen MMGM]]
[[Category: Usyal H]]