View source for 2xtd


==Structure of the TBL1 tetramerisation domain==
<StructureSection load='2xtd' size='340' side='right'caption='[[2xtd]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XTD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [https://pdbe.org/2xtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [https://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TBL1X_HUMAN TBL1X_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Eukaryotic transcriptional repressors function by recruiting large coregulatory complexes that target histone deacetylase enzymes to gene promoters and enhancers. Transcriptional repression complexes, assembled by the corepressor NCoR and its homolog SMRT, are crucial in many processes, including development and metabolic physiology. The core repression complex involves the recruitment of three proteins, HDAC3, GPS2 and TBL1, to a highly conserved repression domain within SMRT and NCoR. We have used structural and functional approaches to gain insight into the architecture and biological role of this complex. We report the crystal structure of the tetrameric oligomerization domain of TBL1, which interacts with both SMRT and GPS2, and the NMR structure of the interface complex between GPS2 and SMRT. These structures, together with computational docking, mutagenesis and functional assays, reveal the assembly mechanism and stoichiometry of the corepressor complex.

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.,Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW Nat Struct Mol Biol. 2011 Jan 16. PMID:21240272<ref>PMID:21240272</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2xtd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fairall L]]
[[Category: Greenwood JA]]
[[Category: Oberoi J]]
[[Category: Schwabe JWR]]
[[Category: Watson PJ]]