View source for 2xxz


==Crystal structure of the human JMJD3 jumonji domain==
<StructureSection load='2xxz' size='340' side='right'caption='[[2xxz]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8XQ:8-HYDROXYQUINOLINE-5-CARBOXYLIC+ACID'>8XQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxz OCA], [https://pdbe.org/2xxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxz RCSB], [https://www.ebi.ac.uk/pdbsum/2xxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref> 

==See Also==
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Che KH]]
[[Category: Daniel M]]
[[Category: Edwards A]]
[[Category: Filippakopoulos P]]
[[Category: Krojer T]]
[[Category: Muniz JRC]]
[[Category: Ng SS]]
[[Category: Oppermann U]]
[[Category: Savitsky P]]
[[Category: Tumber A]]
[[Category: Ugochukwu E]]
[[Category: Weigelt J]]
[[Category: Yue WW]]