View source for 2xzz


==Crystal structure of the human transglutaminase 1 beta-barrel domain==
<StructureSection load='2xzz' size='340' side='right'caption='[[2xzz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xzz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzz OCA], [https://pdbe.org/2xzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xzz RCSB], [https://www.ebi.ac.uk/pdbsum/2xzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xzz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TGM1_HUMAN TGM1_HUMAN] Lamellar ichthyosis;Self-healing collodion baby;Bathing suit ichthyosis;Acral self-healing collodion baby;Congenital non-bullous ichthyosiform erythroderma. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TGM1_HUMAN TGM1_HUMAN] Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Allerston C]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Chaikuad A]]
[[Category: Cooper C]]
[[Category: Edwards A]]
[[Category: Kavanagh K]]
[[Category: Krojer T]]
[[Category: Krysztofinska E]]
[[Category: Oppermann U]]
[[Category: Vollmar M]]
[[Category: Weigelt J]]
[[Category: Yue WW]]
[[Category: Von Delft F]]