View source for 2y7j


==Structure of human phosphorylase kinase, gamma 2==
<StructureSection load='2y7j' size='340' side='right'caption='[[2y7j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7j OCA], [https://pdbe.org/2y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7j RCSB], [https://www.ebi.ac.uk/pdbsum/2y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7j ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).<ref>PMID:10487978</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Berridge G]]
[[Category: Bountra C]]
[[Category: Brenner B]]
[[Category: Burgess-Brown N]]
[[Category: Che KH]]
[[Category: Edwards AM]]
[[Category: Elkins JM]]
[[Category: Fedorov O]]
[[Category: Knapp S]]
[[Category: Krojer T]]
[[Category: Muniz JRC]]
[[Category: Rellos P]]
[[Category: Savitsky P]]
[[Category: Shrestha A]]
[[Category: Vollmar M]]
[[Category: Wang J]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]