View source for 2ydt


==STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A from FUSARIUM Graminearum in complexe with an iminosugar inhibitor==
<StructureSection load='2ydt' size='340' side='right'caption='[[2ydt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ydt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YDT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=EDG:1,4-DIDEOXY-1,4-IMINO-L-ARABINITOL'>EDG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ydt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ydt OCA], [https://pdbe.org/2ydt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ydt RCSB], [https://www.ebi.ac.uk/pdbsum/2ydt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ydt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B8ZY56_GIBZA B8ZY56_GIBZA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
As part of continued efforts to understand the mechanisms of 1,5-alpha-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant.

alpha-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors.,Goddard-Borger ED, Carapito R, Jeltsch JM, Phalip V, Stick RV, Varrot A Chem Commun (Camb). 2011 Sep 14;47(34):9684-6. Epub 2011 Jul 20. PMID:21773614<ref>PMID:21773614</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2ydt" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fusarium graminearum]]
[[Category: Large Structures]]
[[Category: Carapito R]]
[[Category: Goddard-Borger ED]]
[[Category: Jeltsch JM]]
[[Category: Phalip V]]
[[Category: Stick RV]]
[[Category: Varrot A]]