View source for 2yeo


==A39L mutation of scorpion toxin lqh-alpha-it==
<StructureSection load='2yeo' size='340' side='right'caption='[[2yeo]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2yeo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.08&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DR0:N-(HYDROXYMETHYL)-N,N-DIMETHYLHEXAN-1-AMINIUM'>DR0</scene>, <scene name='pdbligand=DR8:N,N,N-TRIMETHYLHEPTA-1,3,5-TRIYN-1-AMINIUM'>DR8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yeo OCA], [https://pdbe.org/2yeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yeo RCSB], [https://www.ebi.ac.uk/pdbsum/2yeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yeo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCXA_LEIHE SCXA_LEIHE] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Leiurus quinquestriatus hebraeus]]
[[Category: Frolow F]]
[[Category: Gurevitz M]]
[[Category: Kahn R]]