View source for 2yqe


==Solution structure of the ARID domain of JARID1D protein==
<StructureSection load='2yqe' size='340' side='right'caption='[[2yqe]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2yqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqe OCA], [https://pdbe.org/2yqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yqe RCSB], [https://www.ebi.ac.uk/pdbsum/2yqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yqe ProSAT], [https://www.topsan.org/Proteins/RSGI/2yqe TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDM5D_HUMAN KDM5D_HUMAN] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.<ref>PMID:17320160</ref> <ref>PMID:17320162</ref> <ref>PMID:17351630</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yq/2yqe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yqe ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Muto Y]]
[[Category: Shirouzu M]]
[[Category: Suzuki S]]
[[Category: Tanabe W]]
[[Category: Terada T]]
[[Category: Yokoyama S]]