View source for 2yru


==Solution structure of mouse Steroid receptor RNA activator 1 (SRA1) protein==
<StructureSection load='2yru' size='340' side='right'caption='[[2yru]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2yru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yru OCA], [https://pdbe.org/2yru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yru RCSB], [https://www.ebi.ac.uk/pdbsum/2yru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yru ProSAT], [https://www.topsan.org/Proteins/RSGI/2yru TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRA1_MOUSE SRA1_MOUSE] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).[UniProtKB:Q9HD15]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/2yru_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yru ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Nameki N]]
[[Category: Saito K]]
[[Category: Yokoyama S]]