View source for 2ysg


==Solution structure of the WW domain from the human syntaxin-binding protein 4==
<StructureSection load='2ysg' size='340' side='right'caption='[[2ysg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ysg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YSG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ysg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ysg OCA], [https://pdbe.org/2ysg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ysg RCSB], [https://www.ebi.ac.uk/pdbsum/2ysg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ysg ProSAT], [https://www.topsan.org/Proteins/RSGI/2ysg TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STXB4_HUMAN STXB4_HUMAN] Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/2ysg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ysg ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Syntaxin-binding protein|Syntaxin-binding protein]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Harada T]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Ohnishi S]]
[[Category: Sato M]]
[[Category: Tochio N]]
[[Category: Watanabe S]]
[[Category: Yokoyama S]]