View source for 2ysr


==Solution structure of the DEP domain from human DEP domain-containing protein 1==
<StructureSection load='2ysr' size='340' side='right'caption='[[2ysr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ysr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YSR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ysr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ysr OCA], [https://pdbe.org/2ysr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ysr RCSB], [https://www.ebi.ac.uk/pdbsum/2ysr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ysr ProSAT], [https://www.topsan.org/Proteins/RSGI/2ysr TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEP1A_HUMAN DEP1A_HUMAN] May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/2ysr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ysr ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hayahsi F]]
[[Category: Yokoyama S]]
[[Category: Zhang HP]]