View source for 2yt5


==Solution structure of the PHD domain of Metal-response element-binding transcription factor 2==
<StructureSection load='2yt5' size='340' side='right'caption='[[2yt5]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2yt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YT5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yt5 OCA], [https://pdbe.org/2yt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yt5 RCSB], [https://www.ebi.ac.uk/pdbsum/2yt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yt5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTF2_MOUSE MTF2_MOUSE] Binds to the metal-regulating-element (MRE) of metallothionein-1A gene promoter. Binding is zinc-dependent.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yt/2yt5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yt5 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Harada T]]
[[Category: Isono K]]
[[Category: Kigawa T]]
[[Category: Koseki H]]
[[Category: Masuda K]]
[[Category: Muto Y]]
[[Category: Watanabe S]]
[[Category: Yokoyama S]]