View source for 2ywk


==Crystal structure of RRM-domain derived from human putative RNA-binding protein 11==
<StructureSection load='2ywk' size='340' side='right'caption='[[2ywk]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ywk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YWK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ywk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ywk OCA], [https://pdbe.org/2ywk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ywk RCSB], [https://www.ebi.ac.uk/pdbsum/2ywk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ywk ProSAT], [https://www.topsan.org/Proteins/RSGI/2ywk TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBM11_HUMAN RBM11_HUMAN] Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.<ref>PMID:21984414</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2ywk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ywk ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kaminishi T]]
[[Category: Kawazoe M]]
[[Category: Morita S]]
[[Category: Nishino A]]
[[Category: Shirouzu M]]
[[Category: Takemoto C]]
[[Category: Terada T]]
[[Category: Uchikubo-Kamo T]]
[[Category: Yokoyama S]]