View source for 32ja


==Structure of the pathogenic variant T186R of Human SHMT2 in the apo open dimeric conformation==
<StructureSection load='32ja' size='340' side='right'caption='[[32ja]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[32ja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=32JA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=32JA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=32ja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=32ja OCA], [https://pdbe.org/32ja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=32ja RCSB], [https://www.ebi.ac.uk/pdbsum/32ja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=32ja ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLYM_HUMAN GLYM_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.<ref>PMID:21876188</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Boumis G]]
[[Category: Breccia S]]
[[Category: Di Matteo A]]
[[Category: Giardina G]]