View source for 32yy


==Cryo-EM structure of native, mature HERV-K pentameric capsomer==
<StructureSection load='32yy' size='340' side='right'caption='[[32yy]], [[Resolution|resolution]] 3.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[32yy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_endogenous_retrovirus_K Human endogenous retrovirus K]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=32YY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=32YY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=32yy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=32yy OCA], [https://pdbe.org/32yy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=32yy RCSB], [https://www.ebi.ac.uk/pdbsum/32yy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=32yy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAK8_HUMAN GAK8_HUMAN] The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
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</StructureSection>
[[Category: Human endogenous retrovirus K]]
[[Category: Large Structures]]
[[Category: Lyu C]]
[[Category: Shen Y]]
[[Category: Zhang P]]