View source for 35ui


==Crystal structure of TFPI K2 domain in complex with TFPI-24 Fab fragment==
<StructureSection load='35ui' size='340' side='right'caption='[[35ui]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[35ui]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=35UI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=35UI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=35ui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=35ui OCA], [https://pdbe.org/35ui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=35ui RCSB], [https://www.ebi.ac.uk/pdbsum/35ui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=35ui ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q2PFV4_MACFA Q2PFV4_MACFA] Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.[ARBA:ARBA00057773]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Macaca fascicularis]]
[[Category: Juo ZS]]
[[Category: Mosyak L]]