View source for 36jf


==Crystal structure of Yck2 from Candida albicans in complex with kinase inhibitor MN-II-74: 4-(2-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyridin-3-yl)pyridin-2-amine==
<StructureSection load='36jf' size='340' side='right'caption='[[36jf]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[36jf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=36JF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=36JF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1DLQ:4-[2-(4-fluorophenyl)-6-methyl-pyrazolo[1,5-a]pyridin-3-yl]pyridin-2-amine'>A1DLQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=36jf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=36jf OCA], [https://pdbe.org/36jf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=36jf RCSB], [https://www.ebi.ac.uk/pdbsum/36jf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=36jf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YCK2_CANAL YCK2_CANAL] Serine/threonine protein kinase required to cause normal damage to epithelial cells and resist antimicrobial peptides.<ref>PMID:19700637</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Candida albicans SC5314]]
[[Category: Large Structures]]
[[Category: Cowen LE]]
[[Category: Joachimiak A]]
[[Category: Lemak S]]
[[Category: Prive GG]]
[[Category: Satchell KJF]]
[[Category: Savchenko A]]
[[Category: Stogios PJ]]
[[Category: Williams A]]