View source for 36nb


==Crystal structure of the NKX2-1 homeodomain bound to a palindromic DNA recognition sequence==
<StructureSection load='36nb' size='340' side='right'caption='[[36nb]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[36nb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=36NB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=36NB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.26&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=36nb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=36nb OCA], [https://pdbe.org/36nb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=36nb RCSB], [https://www.ebi.ac.uk/pdbsum/36nb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=36nb ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NKX21_HUMAN NKX21_HUMAN] Benign hereditary chorea;Differentiated thyroid carcinoma;Athyreosis;Brain-lung-thyroid syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  Disease susceptibility is associated with variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NKX21_HUMAN NKX21_HUMAN] Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).[UniProtKB:P23441][UniProtKB:P50220]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Nam HJ]]