View source for 38hm


==Cryo-EM Structure of GTP Cyclohydrolase I from Candida albicans bound to 7-Deaza GTP and BH2 at 1.96 A==
<StructureSection load='38hm' size='340' side='right'caption='[[38hm]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[38hm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=38HM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=38HM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=QBQ:[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-4-oxidanylidene-3~{H}-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>QBQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=38hm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=38hm OCA], [https://pdbe.org/38hm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=38hm RCSB], [https://www.ebi.ac.uk/pdbsum/38hm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=38hm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C4YRY1_CANAW C4YRY1_CANAW] GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.[ARBA:ARBA00055676]
__TOC__
</StructureSection>
[[Category: Candida albicans]]
[[Category: Large Structures]]
[[Category: Borek D]]
[[Category: Guo Y]]
[[Category: Klose T]]
[[Category: Mesecar AD]]
[[Category: Oluwarotimi EA]]
[[Category: Vago F]]