View source for 3aqz


==Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain with laminarihexaoses==
<StructureSection load='3aqz' size='340' side='right'caption='[[3aqz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3aqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plodia_interpunctella Plodia interpunctella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aqz OCA], [https://pdbe.org/3aqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aqz RCSB], [https://www.ebi.ac.uk/pdbsum/3aqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aqz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGBP_PLOIN BGBP_PLOIN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Innate ability to detect pathogens is achieved by pattern recognition receptors (PRRs) which recognise non-self components such as beta1,3-glucan. beta1,3-Glucans form a triple-helical structure stabilised by inter-chain hydrogen bonds. beta1,3-Glucan recognition protein (betaGRP)/gram-negative bacteria-binding protein 3 (GNBP3), one of PPRs, binds to long, structured beta1,3-glucan to initiate innate immune response. However, binding details and how specificity is achieved in such receptors remain important outstanding issues. We solved the crystal structures of the N-terminal beta1,3-glucan recognition domain of betaGRP/GNBP3 (betaGRP-N) in complex with the beta1,3-linked glucose hexamer, laminarihexaose. In the crystals, three structured laminarihexaoses simultaneously interact through six glucose residues (two from each chain) with one betaGRP-N. The spatial arrangement of the laminarihexaoses bound to betaGRP-N is almost identical to that of a beta1,3-glucan triplex. Therefore, our crystallographic structures together with site-directed mutagenesis data provide a structural basis for the unique recognition by such receptors of the triple-helix structure of beta1,3-glucan.

Structural insights into recognition of triple-helical {beta}-glucan by insect fungal receptor.,Kanagawa M, Satoh T, Ikeda A, Adachi Y, Ohno N, Yamaguchi Y J Biol Chem. 2011 Jun 22. PMID:21697086<ref>PMID:21697086</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3aqz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plodia interpunctella]]
[[Category: Adachi Y]]
[[Category: Ikeda A]]
[[Category: Kanagawa M]]
[[Category: Ohno N]]
[[Category: Satoh T]]
[[Category: Yamaguchi Y]]