View source for 3awi


==Bifunctional tRNA modification enzyme MnmC from Escherichia coli==
<StructureSection load='3awi' size='340' side='right'caption='[[3awi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3awi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AWI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3awi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3awi OCA], [https://pdbe.org/3awi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3awi RCSB], [https://www.ebi.ac.uk/pdbsum/3awi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3awi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MNMC_ECOLI MNMC_ECOLI] Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.<ref>PMID:15247431</ref> <ref>PMID:18186482</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Bessho Y]]
[[Category: Kitamura A]]
[[Category: Nishimoto M]]
[[Category: Sengoku T]]
[[Category: Yokoyama S]]