View source for 3bhd


==Crystal structure of human thiamine triphosphatase (THTPA)==
<StructureSection load='3bhd' size='340' side='right'caption='[[3bhd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3bhd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BHD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bhd OCA], [https://pdbe.org/3bhd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bhd RCSB], [https://www.ebi.ac.uk/pdbsum/3bhd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bhd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THTPA_HUMAN THTPA_HUMAN] Hydrolase highly specific for thiamine triphosphate (ThTP).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/3bhd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bhd ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Berglund H]]
[[Category: Busam RD]]
[[Category: Collins R]]
[[Category: Dahlgren LG]]
[[Category: Edwards AM]]
[[Category: Flodin S]]
[[Category: Flores A]]
[[Category: Graslund S]]
[[Category: Hallberg BM]]
[[Category: Hammarstrom M]]
[[Category: Herman MD]]
[[Category: Johansson A]]
[[Category: Johansson I]]
[[Category: Kallas A]]
[[Category: Karlberg T]]
[[Category: Kotenyova T]]
[[Category: Lehtio L]]
[[Category: Moche M]]
[[Category: Nilsson ME]]
[[Category: Nordlund P]]
[[Category: Nyman T]]
[[Category: Persson C]]
[[Category: Sagemark J]]
[[Category: Sundstrom M]]
[[Category: Svensson L]]
[[Category: Thorsell AG]]
[[Category: Tresaugues L]]
[[Category: Van den Berg S]]
[[Category: Weigelt J]]
[[Category: Welin M]]