View source for 3bjg


==Structure of Rivax: A Human Ricin Vaccine==
<StructureSection load='3bjg' size='340' side='right' caption='[[3bjg]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3bjg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Castor_bean Castor bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjg OCA], [http://pdbe.org/3bjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bjg RCSB], [http://www.ebi.ac.uk/pdbsum/3bjg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjg ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). 

==See Also==
*[[Ricin|Ricin]]
__TOC__
</StructureSection>
[[Category: Castor bean]]
[[Category: RRNA N-glycosylase]]
[[Category: Legler, P M]]
[[Category: Millard, C B]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Lectin]]
[[Category: Plant defense]]
[[Category: Protein synthesis inhibitor]]
[[Category: Ribosome inactivating protein]]
[[Category: Ricin a chain]]
[[Category: Toxin]]
[[Category: Vaccine]]