View source for 3cni


==Crystal structure of a domain of a putative ABC type-2 transporter from Thermotoga maritima MSB8==
<StructureSection load='3cni' size='340' side='right'caption='[[3cni]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3cni]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CNI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TM_0543 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cni OCA], [https://pdbe.org/3cni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cni RCSB], [https://www.ebi.ac.uk/pdbsum/3cni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cni ProSAT], [https://www.topsan.org/Proteins/MCSG/3cni TOPSAN]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cn/3cni_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cni ConSurf].
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== Publication Abstract from PubMed ==
This study describes the structure of the putative ABC-type 2 transporter TM0543 from Thermotoga maritima MSB8 determined at a resolution of 2.3 A. In comparative sequence-clustering analysis, TM0543 displays similarity to NatAB-like proteins, which are components of the ABC-type Na+ efflux pump permease. However, the overall structure fold of the predicted nucleotide-binding domain reveals that it is different from any known structure of ABC-type efflux transporters solved to date. The structure of the putative TM0543 domain also exhibits different dimer architecture and topology of its presumed ATP binding pocket, which may indicate that it does not bind nucleotide at all. Structural analysis of calcium ion binding sites found at the interface between TM0543 dimer subunits suggests that protein may be involved in ion-transporting activity. A detailed analysis of the protein sequence and structure is presented and discussed.

Structural characterization of the putative ABC-type 2 transporter from Thermotoga maritima MSB8.,Filippova EV, Tkaczuk KL, Chruszcz M, Xu X, Savchenko A, Edwards A, Minor W J Struct Funct Genomics. 2014 Oct 12. PMID:25306867<ref>PMID:25306867</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3cni" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thema]]
[[Category: Chruszcz, M]]
[[Category: Cymborowski, M]]
[[Category: Edwards, A M]]
[[Category: Filippova, E V]]
[[Category: Joachimiak, A]]
[[Category: Structural genomic]]
[[Category: Minor, W]]
[[Category: Que, Q]]
[[Category: Savchenko, A]]
[[Category: Shumilin, I]]
[[Category: Tkaczuk, K L]]
[[Category: Xu, X]]
[[Category: Abc type-2 transporter]]
[[Category: Mcsg]]
[[Category: PSI, Protein structure initiative]]
[[Category: Thermotoga maritima]]
[[Category: Transport protein]]