View source for 3fww


==The crystal structure of the bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase from Yersinia pestis CO92==
<StructureSection load='3fww' size='340' side='right'caption='[[3fww]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3fww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_Pestoides_F Yersinia pestis Pestoides F]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fww OCA], [https://pdbe.org/3fww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fww RCSB], [https://www.ebi.ac.uk/pdbsum/3fww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fww ProSAT], [https://www.topsan.org/Proteins/CSGID/3fww TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLMU_YERPP GLMU_YERPP] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.[HAMAP-Rule:MF_01631]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fww_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fww ConSurf].
<div style="clear:both"></div>

==See Also==
*[[N-acetylglucosamine-1-phosphate uridyltransferase|N-acetylglucosamine-1-phosphate uridyltransferase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Yersinia pestis Pestoides F]]
[[Category: Anderson W]]
[[Category: Gu M]]
[[Category: Joachimiak A]]
[[Category: Stam J]]
[[Category: Zhang R]]