View source for 3guu


==X-ray structure of Candida Antarctica lipase A==
<StructureSection load='3guu' size='340' side='right'caption='[[3guu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3guu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moesziomyces_antarcticus Moesziomyces antarcticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GUU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3guu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3guu OCA], [https://pdbe.org/3guu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3guu RCSB], [https://www.ebi.ac.uk/pdbsum/3guu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3guu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LIPA_MOEAP LIPA_MOEAP] Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8). Has the highest activity with tributyrin (C4), followed by tricaproin (C6) and tricaprylin (C8). Can also hydrolyze vinylacetate (C2) and triolein (C18), but with lower efficiency. Has no activity with tripalmitin (C16).<ref>PMID:16575565</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/3guu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3guu ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Lipase 3D Structures|Lipase 3D Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Moesziomyces antarcticus]]
[[Category: Airenne T]]
[[Category: Brandt A-M]]
[[Category: Kanerva LT]]
[[Category: Li X-G]]
[[Category: Nymalm-Rejstrom Y]]
[[Category: Salminen TA]]