View source for 3gyt


==Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 4==
<StructureSection load='3gyt' size='340' side='right'caption='[[3gyt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3gyt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Strongyloides_stercoralis Strongyloides stercoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GYT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DL4:(14BETA,17ALPHA,25R)-3-OXOCHOLEST-4-EN-26-OIC+ACID'>DL4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gyt OCA], [https://pdbe.org/3gyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gyt RCSB], [https://www.ebi.ac.uk/pdbsum/3gyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gyt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9XZJ5_STRER Q9XZJ5_STRER] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/3gyt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gyt ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Strongyloides stercoralis]]
[[Category: Auchus RJ]]
[[Category: Conneely A]]
[[Category: Kliewer SA]]
[[Category: Mangelsdorf DJ]]
[[Category: Motola DL]]
[[Category: Ogata C]]
[[Category: Sharma KK]]
[[Category: Suino-Powell K]]
[[Category: Wang Z]]
[[Category: Xu HE]]
[[Category: Zhou XE]]