View source for 3hag


==Crystal structure of the Hepatitis E Virus-like Particle==
<StructureSection load='3hag' size='340' side='right'caption='[[3hag]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3hag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthohepevirus_A Orthohepevirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HAG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hag OCA], [https://pdbe.org/3hag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hag RCSB], [https://www.ebi.ac.uk/pdbsum/3hag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hag ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_HEVCT CAPSD_HEVCT] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.[UniProtKB:Q9YLQ9]  Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P29326][UniProtKB:P33426][UniProtKB:Q81871]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Orthohepevirus A]]
[[Category: Guu TSY]]
[[Category: Li K]]
[[Category: Liu Z]]
[[Category: Mata DA]]
[[Category: Tao YJ]]
[[Category: Ye Q]]
[[Category: Yin C]]
[[Category: Zhang J]]