View source for 3hiv


==Crystal structure of Saporin-L1 in complex with the trinucleotide inhibitor, a transition state analogue==
<StructureSection load='3hiv' size='340' side='right'caption='[[3hiv]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3hiv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saponaria_officinalis Saponaria officinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HIV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TXN:(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-3,6-DIHYDRO-9H-PURIN-9-YL)-2-({[(S)-({(3R,4R)-4-({[(S)-{[(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-6,8-DIHYDRO-9H-PURIN-9-YL)-2-(HYDROXYMETHYL)-4-METHOXYTETRAHYDROFURAN-3-YL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]PYRROLIDIN-3-YL}OXY)(HYDROXY)PHOSPHORYL]OXY}METHYL)-4-METHOXYTETRAHYDROFURAN-3-YL+3-HYDROXYPROPYL+HYDROGEN+(S)-PHOSPHATE'>TXN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hiv OCA], [https://pdbe.org/3hiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hiv RCSB], [https://www.ebi.ac.uk/pdbsum/3hiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hiv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q2QEH4_SAPOF Q2QEH4_SAPOF] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/3hiv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hiv ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saponaria officinalis]]
[[Category: Almo SC]]
[[Category: Ho M]]
[[Category: Schramm VL]]
[[Category: Sturm MB]]