View source for 3irc


==Crystal structure analysis of dengue-1 envelope protein domain III==
<StructureSection load='3irc' size='340' side='right'caption='[[3irc]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3irc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3egp 3egp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IRC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irc OCA], [https://pdbe.org/3irc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3irc RCSB], [https://www.ebi.ac.uk/pdbsum/3irc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3irc ProSAT], [https://www.topsan.org/Proteins/CSGID/3irc TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9J7C6_9FLAV Q9J7C6_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
__TOC__
</StructureSection>
[[Category: Dengue virus 1]]
[[Category: Large Structures]]
[[Category: Chruszcz M]]
[[Category: Fremont DH]]
[[Category: Kim T]]
[[Category: Minor W]]
[[Category: Nelson CA]]
[[Category: Warren JT]]