View source for 3iyp


==The Interaction of Decay-accelerating Factor with Echovirus 7==
<SX load='3iyp' size='340' side='right' viewer='molstar' caption='[[3iyp]], [[Resolution|resolution]] 7.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3iyp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_E7 Echovirus E7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyp OCA], [https://pdbe.org/3iyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iyp RCSB], [https://www.ebi.ac.uk/pdbsum/3iyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q91QV1_9ENTO Q91QV1_9ENTO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Echovirus 7 (EV7) belongs to the enterovirus genus within the family Picornaviridae. Many picornaviruses use IgG-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, in addition, some of the enteroviruses use an alternative or additional receptor that binds outside the canyon. Decay-accelerating factor (DAF) has been identified as a cellular receptor for EV7. The crystal structure of EV7 has been determined to 3.1 A resolution and used to interpret the 7.2 A resolution cryo-electron microscopy reconstruction of EV7 complexed with DAF. Each DAF binding site on EV7 is near a two-fold icosahedral symmetry axis, which differs from the binding site of DAF on the surface of coxsackievirus B3, indicating independent evolutionary processes by which DAF has been selected as a picornavirus accessory receptor. This suggests that there is an advantage for these viruses to recognize DAF during the initial process of infection.

The Interaction of Decay-accelerating Factor with Echovirus 7.,Plevka P, Hafenstein S, Harris KG, Cifuente JO, Zhang Y, Bowman VD, Chipman PR, Bator CM, Lin F, Medof ME, Rossmann MG J Virol. 2010 Sep 29. PMID:20881044<ref>PMID:20881044</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3iyp" style="background-color:#fffaf0;"></div>

==See Also==
*[[CD55|CD55]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Echovirus E7]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bator CM]]
[[Category: Bowman VD]]
[[Category: Chipman PR]]
[[Category: Cifuente JO]]
[[Category: Hafenstein S]]
[[Category: Harris KG]]
[[Category: Lin F]]
[[Category: Medof DE]]
[[Category: Plevka P]]
[[Category: Rossmann MG]]
[[Category: Zhang Y]]