View source for 3iys


==Homology model of avian polyomavirus asymmetric unit==
<SX load='3iys' size='340' side='right' viewer='molstar' caption='[[3iys]], [[Resolution|resolution]] 11.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3iys]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Aves_polyomavirus_1 Aves polyomavirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iys OCA], [https://pdbe.org/3iys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iys RCSB], [https://www.ebi.ac.uk/pdbsum/3iys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iys ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP1_BFPYV VP1_BFPYV] Forms an icosahedral capsid with a T=7 symmetry and a 46-48 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA (By similarity).

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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</SX>
[[Category: Aves polyomavirus 1]]
[[Category: Large Structures]]
[[Category: Atwood WJ]]
[[Category: Baker TS]]
[[Category: Belnap DM]]
[[Category: Carter WS]]
[[Category: Cheng RH]]
[[Category: Enderlein D]]
[[Category: Johne R]]
[[Category: Kawano M]]
[[Category: Nelson CDS]]
[[Category: Olson NH]]
[[Category: Shen PS]]
[[Category: Swenson RD]]
[[Category: Xing L]]