View source for 3izq


==Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome==
<SX load='3izq' size='340' side='right' viewer='molstar' caption='[[3izq]], [[Resolution|resolution]] 9.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3izq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izq OCA], [https://pdbe.org/3izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izq RCSB], [https://www.ebi.ac.uk/pdbsum/3izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOM34_YEAST DOM34_YEAST] Involved in protein translation. Together with HBS1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by DOM34 and HBS1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of HBS1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.<ref>PMID:16554824</ref> <ref>PMID:17889667</ref> <ref>PMID:18180287</ref> 
== References ==
<references/>
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</SX>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Abdel Motaal B]]
[[Category: Anger AM]]
[[Category: Armache J-P]]
[[Category: Becker T]]
[[Category: Beckmann R]]
[[Category: Berninghausen O]]
[[Category: Jarasch A]]
[[Category: Mielke T]]
[[Category: Sieber H]]
[[Category: Villa E]]