View source for 3izz


==Models for ribosome components that are nearest neighbors to the bovine mitochondrial initiation factor2 bound to the E. Coli ribosome==
<SX load='3izz' size='340' side='right' viewer='molstar' caption='[[3izz]], [[Resolution|resolution]] 10.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3izz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izz OCA], [https://pdbe.org/3izz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izz RCSB], [https://www.ebi.ac.uk/pdbsum/3izz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL14_ECOLI RL14_ECOLI] This protein binds directly to 23S ribosomal RNA. In the E.coli 70S ribosome (PubMed:12809609) it has been modeled to make two contacts with the 16S rRNA of the 30S subunit, forming part of bridges B5 and B8, connecting the 2 subunits. Although the protein undergoes significant rotation during the transition from an initiation to and EF-G bound state, the bridges remain stable. In the 3.5 A resolved structures (PubMed:16272117) L14 and L19 interact and together make contact with the 16S rRNA in bridges B5 and B8.<ref>PMID:22829778</ref>   Can also interact with RsfA, in this case bridge B8 probably cannot form, and the 30S and 50S ribosomal subunits do not associate, which represses translation.<ref>PMID:22829778</ref> 
== References ==
<references/>
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Agrawal RK]]
[[Category: Banavali NK]]
[[Category: Datta PP]]
[[Category: Elmore K]]
[[Category: Haque E]]
[[Category: Spremulli LL]]
[[Category: Yassin AS]]