View source for 3j05


==Three-dimensional structure of Dengue virus serotype 1 complexed with HMAb 14c10 Fab==
<SX load='3j05' size='340' side='right' viewer='molstar' caption='[[3j05]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j05]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J05 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j05 OCA], [https://pdbe.org/3j05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j05 RCSB], [https://www.ebi.ac.uk/pdbsum/3j05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j05 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q689G3_9FLAV Q689G3_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]
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[[Category: Dengue virus 1]]
[[Category: Large Structures]]
[[Category: Alonso S]]
[[Category: Chan SH]]
[[Category: Fisher D]]
[[Category: Hanson B]]
[[Category: Kemeny DM]]
[[Category: Kukkaro P]]
[[Category: Leo YS]]
[[Category: Lim A]]
[[Category: Lok SM]]
[[Category: MacAry PA]]
[[Category: Ng G]]
[[Category: Ng ML]]
[[Category: Ooi EE]]
[[Category: Schul W]]
[[Category: Shi PY]]
[[Category: Smith KGC]]
[[Category: Tan TT]]
[[Category: Teo EW]]
[[Category: Teoh EP]]
[[Category: Yip A]]