View source for 3j3s


==Structural dynamics of the MecA-ClpC complex revealed by cryo-EM==
<SX load='3j3s' size='340' side='right' viewer='molstar' caption='[[3j3s]], [[Resolution|resolution]] 11.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j3s]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J3S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j3s OCA], [https://pdbe.org/3j3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j3s RCSB], [https://www.ebi.ac.uk/pdbsum/3j3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j3s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> 
== References ==
<references/>
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[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Gao N]]
[[Category: Lei J]]
[[Category: Li N]]
[[Category: Liu J]]
[[Category: Mei Z]]
[[Category: Qi Y]]
[[Category: Shi Y]]
[[Category: Wang F]]
[[Category: Xu Y]]