View source for 3j3u


==Structural dynamics of the MecA-ClpC complex revealed by cryo-EM==
<SX load='3j3u' size='340' side='right' viewer='molstar' caption='[[3j3u]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j3u]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J3U FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j3u OCA], [https://pdbe.org/3j3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j3u RCSB], [https://www.ebi.ac.uk/pdbsum/3j3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j3u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> 
== References ==
<references/>
__TOC__
</SX>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Gao N]]
[[Category: Lei J]]
[[Category: Li N]]
[[Category: Liu J]]
[[Category: Mei Z]]
[[Category: Qi Y]]
[[Category: Shi Y]]
[[Category: Wang F]]
[[Category: Xu Y]]