View source for 3j7g


==Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments==
<SX load='3j7g' size='340' side='right' viewer='molstar' caption='[[3j7g]], [[Resolution|resolution]] 13.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7G FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 13.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [https://pdbe.org/3j7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [https://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref> 

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
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[[Category: Human papillomavirus type 16]]
[[Category: Large Structures]]
[[Category: Hafenstein S]]
[[Category: Lee H]]