View source for 3jao


==Ciliary microtubule doublet==
<SX load='3jao' size='340' side='right' viewer='molstar' caption='[[3jao]], [[Resolution|resolution]] 23.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JAO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 23&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jao OCA], [https://pdbe.org/3jao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jao RCSB], [https://www.ebi.ac.uk/pdbsum/3jao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jao ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0M3KKT1_TETTH A0A0M3KKT1_TETTH] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.[RuleBase:RU000352]
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</SX>
[[Category: Large Structures]]
[[Category: Tetrahymena thermophila]]
[[Category: Bui KH]]
[[Category: Ishikawa T]]
[[Category: Maheshwari A]]
[[Category: Obbineni JM]]
[[Category: Shibata K]]
[[Category: Toyoshima YY]]