View source for 3jc2


==The structure of the mammalian Sec61 channel opened by a signal sequence==
<SX load='3jc2' size='340' side='right' viewer='molstar' caption='[[3jc2]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jc2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JC2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jc2 OCA], [https://pdbe.org/3jc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jc2 RCSB], [https://www.ebi.ac.uk/pdbsum/3jc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jc2 ProSAT]</span></td></tr>
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== Function ==
[https://www.uniprot.org/uniprot/S61A1_CANLF S61A1_CANLF] 
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== Publication Abstract from PubMed ==
Secreted and integral membrane proteins compose up to one-third of the biological proteome. These proteins contain hydrophobic signals that direct their translocation across or insertion into the lipid bilayer by the Sec61 protein-conducting channel. The molecular basis of how hydrophobic signals within a nascent polypeptide trigger channel opening is not understood. Here, we used cryo-electron microscopy to determine the structure of an active Sec61 channel that has been opened by a signal sequence. The signal supplants helix 2 of Sec61alpha, which triggers a rotation that opens the central pore both axially across the membrane and laterally toward the lipid bilayer. Comparisons with structures of Sec61 in other states suggest a pathway for how hydrophobic signals engage the channel to gain access to the lipid bilayer.

Structure of the Sec61 channel opened by a signal sequence.,Voorhees RM, Hegde RS Science. 2016 Jan 1;351(6268):88-91. doi: 10.1126/science.aad4992. PMID:26721998<ref>PMID:26721998</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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[[Category: Bos taurus]]
[[Category: Canis lupus familiaris]]
[[Category: Large Structures]]
[[Category: Hegde RS]]
[[Category: Voorhees RM]]