View source for 3jcd


==Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4)==
<SX load='3jcd' size='340' side='right' viewer='molstar' caption='[[3jcd]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jcd]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JCD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jcd OCA], [https://pdbe.org/3jcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jcd RCSB], [https://www.ebi.ac.uk/pdbsum/3jcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jcd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL5_ECOLI RL5_ECOLI] This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. Its 5S rRNA binding is significantly enhanced in the presence of L18.[HAMAP-Rule:MF_01333_B]  In the 70S ribosome in the initiation state (PubMed:12809609) was modeled to contact protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; the protein-protein contacts between S13 and L5 in B1b change in the model with bound EF-G implicating this bridge in subunit movement (PubMed:12809609 and PubMed:18723842). In the two 3.5 A resolved ribosome structures (PubMed:16272117) the contacts between L5, S13 and S19 are different, confirming the dynamic nature of this interaction.[HAMAP-Rule:MF_01333_B]  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.[HAMAP-Rule:MF_01333_B]

==See Also==
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Cheng E]]
[[Category: Gao N]]
[[Category: Jiang T]]
[[Category: Liu G]]
[[Category: Low J]]
[[Category: Luo J]]
[[Category: Qin Y]]
[[Category: Shi Y]]
[[Category: Song G]]
[[Category: Wu S]]
[[Category: Yan K]]
[[Category: Zhang D]]